'Between Literature and Science' follows through to its emerging 21st-century future the central insight of 20th-century literary and cultural theory: that language and culture, along with their subsystems and artifacts, are self-referential systems. The book explores the workings of self-reference (and the related performativity) in linguistic utterances and assorted texts, through examples of the more open social-discursive systems of post-structuralism and cultural studies, and into the sciences, where complex systems organized by recursive self-reference are now being embraced as an emergent paradigm. This paradigmatic convergence between the humanities and sciences is autopoetics (adapting biologist Hubert Maturana?s term for ?self-making? systems), and it signals a long-term epistemological shift across the nature/culture divide so definitive for modernity. If cultural theory has taught us that language, because of its self-referential nature, cannot bear simple witness to the world, the new paradigmatic status of self-referential systems in the natural sciences points toward a revived kinship of language and culture with the world: language bears ?witness? to the world.